Be bloody, bold, and resolute; laugh to scorn The power of man, for none of woman born Shall harm Macbeth.
Be violent, brave, and determined; laugh at the power of men, because no one born of a woman will ever harm Macbeth.
Second Apparition · Act 4, Scene 1
The witches' second apparition gives Macbeth what seems like certain protection. Macbeth believes himself invulnerable and relaxes his guard, ordering the murder of Macduff's family. The irony—that Macduff was untimely ripped from his mother's womb—is the engine of the play's final tragedy, showing how our attempt to escape fate binds us to it.